Is OmpK35 Specific for Ceftazadime Penetration?

Is OmpK35 specific for ceftazadime penetration?

Role of Klebsiella pneumoniae OmpK35 porin in antimicrobial resistance.

OmpK35 from Klebsiella pneumoniae is the homologue of Escherichia coli OmpF porin. Expression of OmpK35 in K. pneumoniae strain CSUB10R (lacking both OmpK35 and OmpK36) decreased the MICs of cephalosporins and meropenem > or = 128-fold and decreased the MICs of imipenem, ciprofloxacin, and chloramphenicol > or = 8-fold. MIC reductions by OmpK35 were 4 times (cefepime), 8 times (cefotetan, cefot...

Multi-objective Optimization of a Projectile Tip for Normal Penetration

The main purpose of the present work is multi-objective shape optimization of a projectile tip for impacting and normal penetrating. Velocity drop, weight and inner volume of projectile have been considered as three conflicting objective functions.  For this purpose, at the first step, finite element modeling was done using ABAQUS/Explicit and projectile penetration was examined in different ge...

Methodology for Penetration Testing

Penetration testing is one of the oldest methods for assessing the security of a computer system. The idea behind penetration testing methodologies is that the penetration tester should follow a pre-scripted format during test as dictated by the methodology. A penetration testing methodology was proposed in this research. It is also important to consider a policy that should be followed by both...

Pathways for Skin Penetration

This paper reviews recent fi ndings about three skin penetration pathways (including a “polar pathway”) and four types of penetration enhancers (enzymes, vesicular systems, ceramides and chemical enhancers). This article will review possible ways for compounds to penetrate the skin and interact with it. Four families of enhancers will be discussed, along with their possible mechanisms of action...